Endocrine Abstracts

Introduction: It is critical to consider species differences in translating the findings of obesity-model animals into human pathophysiology. Leptin plays an important role in regulating energy homeostasis. Although much has been learned from genetically obese leptin deficient Lepob/Lepob mice, some flaws were noted in mice as animal models for human diabetes.Methods: To develop a rat leptin-deficient mod...

Introduction: Markedly decreased plasma leptin concentrations in patients with lipodystrophy commonly lead to overeating. Leptin-replacement therapy improves feeding behavior in these patients. The aim of the present study is to clarify neural networks influenced by leptin signals for appetite regulation in the patients with lipodystrophy.Methods: We measured neural responses to visual food stimuli by use of functional magnetic resonance imaging (fMRI) a...